| Andy Murray (1) | Bye | | | | | | |
| Bye | - | Andy Murray (1) | 4 6(5) | | | | |
| Vasek Pospisil | 6(6) 6 6 | Vasek Pospisil | 6 7(7) | | | | |
| Yen-Hsun Lu | 7(8) 4 3 | | | Vasek Pospisil | 7(7) 3 5 | | |
| Dusan Lajovic | 6 6 | | | Dusan Lajovic | 6(4) 6 7 | | |
| Frances Tiafoe | 3 3 | Dusan Lajovic | 6 4 7(7) | | | | |
| Bye | - | Feliciano Lopez (30) | 2 6 6(2) | | | | |
| Feliciano Lopez (30) | Bye | | | | | Dusan Lajovic | 4 6(5) |
| Pablo Carreno Busta (21) | Bye | | | | | Pablo Carreno Busta (21) | 6 7(7) |
| Bye | - | Pablo Carreno Busta (21) | 7 6 | | | | |
| Peter Gojowczyk | 6 3 6 | Peter Gojowczyk | 5 2 | | | | |
| Reilly Opelka | 4 6 1 | | | Pablo Carreno Busta (21) | WO | | |
| Juan Monaco | 3 7(7) 1 | | | Roberto Bautista Agut (16) | | | |
| Adrian Mannarino | 6 6(5) 6 | Adrian Mannarino | 5 2 | | | | |
| Bye | - | Roberto Bautista Agut (16) | 7 6 | | | | |
| Roberto Bautista Agut (16) | Bye | | | | | | |
| David Goffin (11) | Bye | | | | | | |
| Bye | - | David Goffin (11) | 6 3 6 | | | | |
| Tommy Robredo | 1 5 | Karen Khachanov | 4 6 3 | | | | |
| Karen Khachanov | 6 7 | | | David Goffin (11) | 7(7) 6 | | |
| Damir Dzumhur | 6 3 7 | | | Albert Ramos-Vinolas (22) | 6(3) 4 | | |
| Ryan Harrison | 4 6 5 | Damir Dzumhur | 4 7 5 | | | | |
| Bye | - | Albert Ramos-Vinolas (22) | 6 5 7 | | | | |
| Albert Ramos-Vinolas (22) | Bye | | | | | David Goffin (11) | 3 6 3 |
| Pablo Cuevas (27) | Bye | | | | | Pablo Cuevas (27) | 6 3 6 |
| Bye | - | Pablo Cuevas (27) | 7(7) 7(7) | | | | |
| Martin Klizan | 7(8) 6 | Martin Klizan | 6(3) 6(5) | | | | |
| Thiago Monteiro | 6(6) 3 | | | Pablo Cuevas (27) | 6 6 | | |
| Fabio Fognini | 0 7 6 | | | Fabio Fognini | 1 4 | | |
| Konstantin Kravchuk | 6 5 4 | Fabio Fognini | 7(7) 3 6 | | | | |
| Bye | - | Jo-Wilfried Tsonga (7) | 6(4) 6 4 | | | | |
| Jo-Wilfried Tsonga (7) | Bye | | | | | | |
| Stan Wawrinka (3) | Bye | | | | | | |
| Bye | - | Stan Wawrinka (3) | 6 6 | | | | |
| Robin Haase | 4 3 | Paolo Lorenzi | 3 4 | | | | |
| Paolo Lorenzi | 6 6 | | | Stan Wawrinka (3) | 7 6 | | |
| Alexandr Dolgopolov | 6 6 | | | Philipp Kohlschreiber (28) | 5 3 | | |
| Viktor Troicki | 1 4 | Alexandr Dolgopolov | 7(7) 1 ret. | | | | |
| Bye | - | Philipp Kohlschreiber (28) | 6(3) 1 | | | | |
| Philipp Kohlschreiber (28) | Bye | | | | | Stan Wawrinka (3) | 3 6 7(7) |
| Ivo Karlovic (19) | Bye | | | | | Yoshihito Nishioka | 6 3 6(4) |
| Bye | - | Ivo Karlovic (19) | 4 3 | | | | |
| Yoshihito Nishioka | 6 6 | Yoshihito Nishioka | 6 6 | | | | |
| Elias Ymer | 4 1 | | | Yoshihito Nishioka | 1 7(7) 6 | | |
| Bjorn Fratangelo | 6 6 | | | Tomas Berdych (13) | 6 6(5) 4 | | |
| Bernard Tomic | 2 2 | Bjorn Fratangelo | 6(4) 4 | | | | |
| Bye | - | Tomas Berdych (13) | 7(7) 6 | | | | |
| Tomas Berdych (13) | Bye | | | | | | |
| Gael Monfils (10) | Bye | | | | | | |
| Bye | - | Gael Monfils (10) | 3 6 6 | | | | |
| Nikoloz Basilashvili | 5 5 | Darian King | 6 0 1 | | | | |
| Darian King | 7 7 | | | Gael Monfils (10) | 6 6 | | |
| Jordan Thompson | 6 1 0 ret. | | | John Isner (20) | 2 4 | | |
| Mikhail Kukushkin | 1 6 3 | Mikhail Kukushkin | 6(0) 6(6) | | | | |
| Bye | - | John Isner (20) | 7(7) 7(8) | | | | |
| John Isner (20) | Bye | | | | | Gael Monfils (10) | 3 2 |
| Mischa Zverev (29) | Bye | | | | | Dominic Thiem (8) | 6 6 |
| Bye | - | Mischa Zverev (29) | 6 6 | | | | |
| Joao Sousa | 4 6 6 | Joao Sousa | 4 3 | | | | |
| Diego Schwartzman | 6 3 4 | | | Mischa Zverev (29) | 1 4 | | |
| Radu Albot | 6(2) 2 | | | Dominic Thiem (8) | 6 6 | | |
| Jeremy Chardy | 7(7) 6 | Jeremy Chardy | 2 4 | | | | |
| Bye | - | Dominic Thiem (8) | 6 6 | | | | |
| Dominic Thiem (8) | Bye | | | | | | |
| Marin Cilic (6) | Bye | | | | | | |
| Bye | - | Marin Cilic (6) | 6 5 4 | | | | |
| Benoit Paire | 3 2 | Taylor Fritz | 4 7 6 | | | | |
| Taylor Fritz | 6 6 | | | Taylor Fritz | 4 6 3 | | |
| Nicolas Mahut | 3 2 | | | Malek Jaziri | 6 3 6 | | |
| Malek Jaziri | 6 6 | Malek Jaziri | 7 6 | | | | |
| Bye | - | Marcel Granollers (32) | 5 3 | | | | |
| Marcel Granollers (32) | Bye | | | | | Malek Jaziri | 6 6(1) 5 |
| Jack Sock (17) | Bye | | | | | Jack Sock (17) | 4 7(7) 7 |
| Bye | - | Jack Sock (17) | 6 0 6 | | | | |
| Henri Laaksonen | 3 6 6 | Henri Laaksonen | 3 6 4 | | | | |
| Borna Coric | 6 4 2 | | | Jack Sock (17) | 3 6 7(9) | | |
| Daniil Medvedev | 4 4 | | | Grigor Dimitrov (12) | 6 3 6(7) | | |
| Mikhail Youzhny | 6 6 | Mikhail Youzhny | 4 0 | | | | |
| Bye | - | Grigor Dimitrov (12) | 6 6 | | | | |
| Grigor Dimitrov (12) | Bye | | | | | | |
| Lucas Pouille (14) | Bye | | | | | | |
| Bye | - | Lucas Pouille (14) | 6 6 | | | | |
| Santiago Giraldo | 3 4 | Jan-Lennard Struff | 3 2 | | | | |
| Jan-Lennard Struff | 6 6 | | | Lucas Pouille (14) | 4 6 3 | | |
| Donald Young | 7 7(7) | | | Donald Young | 6 1 6 | | |
| Stefan Kozlov | 5 6(5) | Donald Young | 6 3 6 | | | | |
| Bye | - | Sam Querrey (23) | 3 6 3 | | | | |
| Sam Querrey (23) | Bye | | | | | Donald Young | 2 4 |
| Gilles Muller (25) | Bye | | | | | Kei Nishikori (4) | 6 6 |
| Bye | - | Gilles Muller (25) | 7(7) 6 | | | | |
| Renzo Olivo | 4 6 1 | Jiri Vesely | 6(1) 1 | | | | |
| Jiri Vesely | 6 2 6 | | | Gilles Muller (25) | 2 2 | | |
| Dustin Brown | 1 1 | | | Kei Nishikori (4) | 6 6 | | |
| Daniel Evans | 6 6 | Daniel Evans | 3 4 | | | | |
| Bye | - | Kei Nishikori (4) | 6 6 | | | | |
| Kei Nishikori (4) | Bye | | | | | | |
| Rafael Nadal (5) | Bye | | | | | | |
| Bye | - | Rafael Nadal (5) | 6 6 | | | | |
| Guillermo Garcia-Lopez | 6 5 2 | Guido Pella | 3 2 | | | | |
| Guido Pella | 4 7 6 | | | Rafael Nadal (5) | 6 7 | | |
| Pierre-Hugues Herbert | 7(7) 6(1) 6 | | | Fernando Verdasco (26) | 3 5 | | |
| Thomaz Bellucci | 6(5) 7(7) 3 | Pierre-Hugues Herbert | 6(5) 1 | | | | |
| Bye | - | Fernando Verdasco (26) | 7(7) 6 | | | | |
| Fernando Verdasco (26) | Bye | | | | | Rafael Nadal (5) | 2 3 |
| Steve Johnson (24) | Bye | | | | | Roger Federer (9) | 6 6 |
| Bye | - | Steve Johnson (24) | 6 3 7(7) | | | | |
| Kevin Anderson | 6 6 | Kevin Anderson | 4 6 6(4) | | | | |
| Federico Gaio | 1 4 | | | Steve Johnson (24) | 6(3) 6(4) | | |
| Stephane Robert | 6 6 | | | Roger Federer (9) | 7(7) 7(7) | | |
| Dudi Sela | 4 4 | Stephane Robert | 2 1 | | | | |
| Bye | - | Roger Federer (9) | 6 6 | | | | |
| Roger Federer (9) | Bye | | | | | | |
| Nick Kyrgios (15) | Bye | | | | | | |
| Bye | - | Nick Kyrgios (15) | 6 6 | | | | |
| Marius Copil | 7(7) 6(2) 4 | Horacio Zeballos | 3 4 | | | | |
| Horacio Zeballos | 6(5) 7(7) 6 | | | Nick Kyrgios (15) | 6 6 | | |
| Julien Benneteau | 7 4 2 | | | Alexander Zverev (18) | 3 4 | | |
| Facundo Bagnis | 5 6 6 | Facundo Bagnis | 6(10) 3 | | | | |
| Bye | - | Alexander Zverev (18) | 7(12) 6 | | | | |
| Alexander Zverev (18) | Bye | | | | | Nick Kyrgios (15) | 6 7(7) |
| Juan Martin Del Potro (31) | Bye | | | | | Novak Djokovic (2) | 4 6(3) |
| Bye | - | Juan Martin Del Potro (31) | 7(7) 6 | | | | |
| Federico Delbonis | 6 6 | Federico Delbonis | 6(5) 3 | | | | |
| Andrey Kuznetsov | 3 4 | | | Juan Martin Del Potro (31) | 5 6 1 | | |
| Kyle Edmund | 6 6 | | | Novak Djokovic (2) | 7 4 6 | | |
| Gastao Elias | 1 3 | Kyle Edmund | 4 6(5) | | | | |
| Bye | - | Novak Djokovic (2) | 6 7(7) | | | | |
| Novak Djokovic (2) | Bye | | | | | | |
